This paper is a transcript of the dialogue between Carlo Rovelli and Mike Jackson after Rovelli's delivery of the 2021 Annual Mike Jackson Lecture, hosted by the Centre for Systems Studies at the University of Hull. The dialogue covers a range of topics, including how Rovelli developed a sense of curiosity in his youth; the connection between his interests in science and politics; the pathology of disciplinary divisions in academia; the value of Bogdanov's transdisciplinarity; Rovelli's theory of quantum gravity; the notions of granularity, indeterminism and relationality underpinning quantum mechanics; the role of the observer; mistaken uses of quantum mechanics; relational and network views of the world; how the discipline of Physics is becoming more systemic; the concept of levels of analysis in relation to nature and human inquiry; and the future for humanity.